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They do not account for trauma, shame, loneliness, failed self-soothing, or the defensive uses of substances
"You forget how dark you are," he said
The conversation covers how our understanding of obesity as a chronic, relapsing disease has changed over the past 30 years, what the new clinical versus preclinical obesity framework means for how we diagnose and treat it, how GLP-1 drugs work and why they've succeeded where earlier medications failed, what the STEP and SELECT trials revealed about the disease-modifying potential of semaglutide, and how patients and clinicians should be thinking about who these drugs are really for
Wong SY, Lee ARYB, Sia AHJ et al (2024) Effects of Glucagon-Like Peptide-1 receptor agonist (GLP-1RA) on cardiac structure and function: A systematic review and meta-analysis of randomized-controlled trials
