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Several signaling pathways in response to ANG II are mediated by reactive oxygen species (ROS) (78), whose production is increased by ANG II in different cell types through Nox4 (NADPH [Nicotinamide adenine dinucleotide phosphate] oxidase 4) stimulation (21)
- Reduces melanosome transfer, which fades pigmentation
Beyond these canonical targets, v3 integrin overexpression on tumor neo-vasculature and invasive cancer cells enables cRGD peptide-mediated dual targeting of angiogenesis and tumor survival, while nucleolin, aberrantly surface-displayed in proliferating breast cancer cells, offers aptamer-based (AS1411) recognition independent of traditional receptor-ligand paradigms [127]
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