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It should also be noted that the safety profile of orforglipron in ATTAIN-1 was explicitly described as consistent with that of established injectable GLP-1 agents
CJC-1295 Without DAC and DPP-4 Resistance Research Research that led to the identification of the tetrasubstituted GRF backbone confirmed that all maleimido derivatives of hGRF(1-29) sharing the same four amino acid substitutions showed enhanced in vitro stability against DPP-IV and retained bioactivity in GH secretion assays in cultured rat anterior pituitary cells establishing that the tetrasubstituted scaffold itself is responsible for DPP-4 resistance, independent of the DAC albumin-binding moiety
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