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thus, there is a smaller window for weight loss, as body weight defence mechanisms have a greater role in lean mice, potentially confounding the absence of treatment effects
Its important to recognize that abruptly stopping GLP-1 therapy can lead to common challenges, including weight regain and anxiety about ending treatment
doi: 10.1900/RDS.2014.11.202 46 HabeggerKMHeppnerKMGearyNBartnessTJDiMarchiRTschopMH
This is a critical issue, as a decrease in muscle mass leads to a reduction in basal metabolic rate [41, 42], which could hinder the long-term benefits of obesity treatment by impairing the overall metabolic profile
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