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Spray is meaningfully easier to use and carries lower contamination risk than self-injection, but that usability advantage may come at a real cost in absorbed dose
doi:10.1016/j.cels.2018.03.002
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NICE TA664 recommends semaglutide for adults with a BMI of 35 kg/m or above (or 3034.9 kg/m in certain circumstances) alongside at least one weight-related comorbidity, used within a specialist NHS weight management service for a maximum of two years
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