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Heme oxygenase 1 (HO-1) is a protective enzyme with antioxidant, anti-inflammatory and anti-apoptotic effects, which has been intensively studied and plays an important role in diabetic complications
Risks appear particularly elevated in individuals with comorbid depression or BED, where long-term outcomesespecially following discontinuation of pharmacotherapyremain insufficiently studied [143]
Avoid large meals, high-fat foods, and rapid eating, which can trigger nausea once semaglutide begins
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