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Acetoacetyl-CoA and an additional acetyl-CoA are converted to -hydroxy--methylglutaryl-CoA (HMG-CoA: 3-hydroxy-3-methylglutaryl-CoA) by mitochondrial HMG-CoA synthase (encoded by the HMGCS2 gene), an enzyme found in large amounts only in the liver and intestinal epithelial cells

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Evolution of NADPH oxidase inhibitors: selectivity and mechanisms for target engagement