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Semaglutide is clinically indicated for adults with a BMI of 30 or higher, or a BMI of 27 or higher with at least one weight-related comorbidity such as Type 2 diabetes, hypertension, high cholesterol, or cardiovascular disease
Hence, vagal tone may modulate the duration of action of intestinally secreted PYY 336 , but may not be required for short-term signaling ( 336 and its ability to induce Fos expression in the ARC of rats following peripheral administration, indicating blockade of hypothalamic activation (112)
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