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All cell lines tested negative for mycoplasma contamination using a MycoAlert Mycoplasma Detection kit (Lonza, LT07-418)

Heart Palpitations or High Blood Pressure Heart palpitations Increased heart rate Elevated blood pressure Signs and Symptoms of B12 Overdose signs and symptoms of B12 overdose may include: Skin rash or acne Headaches Nausea or diarrhea Anxiety or restlessness Heart palpitations High blood pressure Trouble sleeping How Much Vitamin B12 Is Too Much

### Continue to monitor your health As you proceed with treatment, your provider will likely ask you to keep track of your symptoms and whether they recede

Three major functional domains represent the essence of the KEAP1 protein structure: the N-terminal Broad complex/Tramtrack/Bric brac (BTB) domain, the central intervening region (IVR) and the C-terminal Kelch/Double glycine repeat (DGR) domain [121, 122]