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Although ROS generated under physiological conditions are not harmful, and likely play a signaling role, toxic or pathological conditions that lead to an impairment of mitochondrial function can increase the release of ROS
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What factors ultimately determine the melatonin efficacy as an adjunctive treatment in sepsis, chronic lung disease and hypoxicischemic encephalopathy of the term and preterm infants Introduction Melatonin ( N -acetyl-5-methoxytryptamine) is a ubiquitous molecule present in nature that carries out many functions 1 , manifesting enormous versatility and diversity
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