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It is a substrate: cells need it to run the electron transport chain, generate ATP, and activate a class of repair enzymes called sirtuins and PARPs
In wound healing models, this leads to faster collagen deposition and better tensile strength in the repaired tissue
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LPO affects mainly unsaturated fatty acids in cell membranes, and its products include LOOH, malondialdehyde and 4HNE, the levels of which are increased during ferroptosis (22)
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