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In FRDA, the expression of the encoded protein frataxin was decreased, leading to obstruction of mitochondrial matrix ironsulfur cluster biosynthesis, mitochondrial dysfunction, and mitochondrial iron accumulation, and finally result in increased oxidative stress
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
Excess inventory ties up money that could be invested in other research needs, and even properly stored peptides gradually degrade
They function similarly to diuretics, so hypotension (low blood pressure) can also be a concern
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