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Since reduced anti-coagulant properties and increased pro-inflammatory mediators and reactive oxygen species play important roles in the development of both endothelial dysfunction and atherosclerosis, the association between the two is almost ubiquitous [88]

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In a pilot trial, 11 adults with slow-transit constipation who had been unsuccessful with other therapies used home-based devices to apply interferential therapy, one hour per day, for three months