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Furthermore, although rare, severe toxicities like lactic acidosis are often preceded by a decline in mtDNA copy number together withrising serum lactate, suggesting that serial monitoring in high-risk individuals could allow earlier detection, although current evidence remains limited ( The utility of mtDNA extends to assessing immunological failure and exhaustion
Oz HS, McClain CJ, Nagasawa HT, et al
J Exp Bot 56:17851796 Yamamoto HY, Higashi RM (1978) Violaxanthin de-epoxidase
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