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In addition, the upregulation of microglia and astrocytes causes dysregulated synaptic pruning, leading to synaptic dysfunction in ASD [202, 203]

These medications are contraindicated during pregnancy and should be discontinued when pregnancy is recognized

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If muscle pain is severe, persistent, or accompanied by weakness, dark urine, or significant functional impairment, seek urgent medical attention via NHS 111, your GP, or A&E as appropriate