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LR3 IGF-1 is a modified analog of human IGF-1 with a 13-amino acid extension at the N-terminus and a substitution of Arg at position 3, which significantly reduces its affinity for IGF-binding proteins
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(4) Activated PLC then possibly breaks down a specific component of the cell membrane into two signaling molecules, inositol trisphosphate (IP) and diacylglycerol (DAG)
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