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The benefits you measure with MK-677 are real, but they're artifacts of supraphysiological signaling
Moreover, we found that overexpression of GGCT (E98A) mutant significantly reduced cell proliferation compared with overexpression of wild-type GGCT in PC3 and DU145 cells (Fig
Findings suggested a proliferative effect on somatotroph cells, though less frequent administration reduced these outcomes
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