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In a landmark study known as the STEP (Semaglutide Treatment Effect in People with Obesity) trials, participants receiving once-weekly injections of Semaglutide achieved substantial weight loss ranging from 12% to 15% of their body weight over the course of 68 weeks

By supporting liver functionkey to fat metabolismit promotes healthy weight management and sustained energy

These include the lower abdomen, flanks (love handles), inner and outer thighs, upper arms, and the submental area under the chin

Bone formation occurred through GLP-1 regulation of the Wnt signaling pathway, resulting in a reduction of RANKL expression and increased levels of OPG and osteocalcin