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Preclinical studies have demonstrated that GLP-1R agonists can reduce the accumulation of amyloid plaques, a hallmark of Alzheimer's disease, and improve synaptic function

GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebo-controlled trial

Participants receiving the medication consistently consumed 240 to 290 fewer calories during laboratory meals than those receiving a placebo, even after their weight loss slowed

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