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When a person reaches biological maturity (at age 18 or the completion of bone growth), they may be reassessed using the diagnostic criteria for hEDS
Additionally, as the first CVD to develop in patients with diabetes is often heart failure rather than myocardial infarction [1], it is becoming clear that the pathology of diabetes itself causes heart failure through direct effects on cardiomyocytes and other myocardial cell types
There is a further action that the reduction of HOX transcript antisense RNA (HOTAIR) expression gives rise to cardiomyopathy
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