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3.2 Host hepatic oxidation: from TMA to TMAO Following intestinal absorption, TMA is rapidly oxidized in the liver by flavin monooxygenases (FMOs), specifically FMO1 and FMO3
Lobello et al., 2016), which might be due to irons induction of excess ROS (Zhang et al., 2020e)
By contrast, cancer cells typically co-express MCT1 and MCT4, facilitating highly efficient lactate efflux that preserves intracellular pH homeostasis even within the acidic tumor microenvironment (127)
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