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Endotoxins activate specific membrane receptors termed Toll-like receptors that are members of a class of pro-inflammatory receptors hat recognize pro-inflammatory molecules termed pattern-associated molecular patterns or PAMPS that in turn can activate genes that initiate inflammatory cascades in the host [49, 65]

Benvenga S, Tuccari G, Ieni A, Vita R (2018) Thyroid gland: anatomy and physiology

Disease severity also depends on the specific target of these IgG [170, 171, 178, 179]

Further studies are required to answer these questions and dissect the exact relationship between ferroptosis, autophagy, and SIPS in RPE