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The most commonly reported side effects in the Phase 2 trial were gastrointestinal in nature, consistent with the broader GLP-1 receptor agonist drug class
These aren't minor gaps, they represent the entire translational bridge that would need to be built before canine research could meaningfully extend the rodent findings
Furthermore, the STEP 3 trial demonstrated that combining the medication with intensive behavioral therapy and a low-calorie diet resulted in a 16.0 percent reduction at week 68 (Source: STEP 3 Trial, Wadden et al., JAMA 2021)
HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved
