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Side Effects Comparison Both medications share similar side effect profiles, mainly affecting your digestive system: Nausea (the most common) Vomiting Diarrhea Constipation Stomach pain According to meta-analysis data, adverse events occurred more frequently with retatrutide (risk ratio: 4.10) compared to tirzepatide (risk ratio: 2.78)

Semaglutide activates GLP-1 receptors throughout your body, lowering appetite, slowing digestion, and regulating blood sugar

DIO-MASH study In the efficacy study, animals were administered vehicle or semaglutide 123 g kg 1 ( n = 16) daily for 8, 16 or 24 weeks

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