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Both medications have different mechanisms and no direct drug-drug interactions, though the additive glucose-lowering effect means patients on additional diabetes medications should monitor for low blood sugar and work closely with their healthcare provider
A history of change within the lesion should be taken seriously as melanoma may arise in congenital melanocytic naevi, especially in giant naevi
Taking a proton pump inhibitor or other medications that reduce stomach acid for reflux or ulcers, as well as taking metformin for diabetes, can reduce absorption of B12 in food or supplements
The choice depends entirely on the objective of the study
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