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B., & Hong, S
TLR4 is highly expressed in microglia, and its signaling pathway is linked to activated microglial phenotypes, which are responsible for the adverse effects of obesity on the hippocampus and other brain regions [47]
Interest in such applications is largely driven by their proposed mechanisms of action, including enhancement of tissue repair, modulation of inflammation, and cytoprotective effects observed in preclinical studies
The remaining 89 papers were retrieved in full-text and four articles were finally included in the systematic review (Fig
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