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Often referred to as the "third eye" due to its light-sensitive regulatory role, the pineal gland serves as the bodys internal timekeeper, synchronizing hormonal rhythms with environmental light cues

Subsequent secondary-source reviews have proposed candidate interactions modulation of GABAergic and glutamatergic tone, possible NMDA-receptor involvement, peripheral 1-adrenergic effects but these have not been replicated in primary studies that establish direct binding or saturable transduction at a defined receptor

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