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Acknowledgements Funding The Improving Diabetes Steering Committee is supported by an educational grant from Napp Pharmaceuticals Limited

Using recently developed biosensors, we explored the ability of GLP-1R to activate 15 pathways in 4 cellular compartments and demonstrate that modifications aimed at improving the therapeutic potential of GLP-1R agonists greatly influence compound efficacy, potency, and safety in a pathway- and compartment-selective manner

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