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The primary endpoint was to demonstrate non-inferiority (with a non-inferiority margin of 0.3%) of tirzepatide 10 mg or 15 mg, or both, compared to glargine in terms of the change in HbA1c from baseline to 52 weeks
Metabolic acidosis has been observed with doses as low as 50 mg/day
2 How to Prevent and Minimize GLP-1 Nausea 1 1 Taking proactive steps with your medication and diet can help you avoid nausea or reduce its severity: Medication Management Start Low, Go Slow: Most GLP-1 medications including Ozempic, Wegovy, Mounjaro and Zepbound are first prescribed at a low dose and gradually increased over several weeks or months
It is a "whole-body" molecule
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