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The main scales for determining disease severity are the Kings College Hospital criteria (KCC)59 and the Clichy-Villejuif criteria,60 among others.61 Currently, the majority of transplantation centers use the KCC (Table 7), which have 68-70% sensitivity and 82-92% specificity, as well as an 80% positive predictive value in paracetamol-related ALF and 70-90% for other etiologies.62 The prognostic score proposed by the Acute Liver Failure Study Group (ALFSG), the ALFSG index, includes HE grade, ALF etiology, vasopressor use, total bilirubin levels, and INR, and is a better predictor of TFS than the MELD or KCC scores.63 However, it must be pointed out that prospective validation of this model is still pending

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Here, we review the mechanistic activity of tirzepatide and its effect on glycemic control, body weight, the cardiorenal system, and lipid metabolism