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The apparent Vmax for various concentrations of inhibitors were used to calculate Ki values

Our ex vivo experiments using single cells isolated from the nodose ganglion revealed that approximately 10% of the neurons exhibited GLP-1-induced increases in cytosolic Ca 2+ concentrations [50]

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1,2 Given that GLP-1 is a large protein, analogs are primarily administered via subcutaneous injection, with the exception of oral semaglutide 7 mg or 14 mg (Rybelsus, Novo Nordisk)