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"Healthy people need less sleep," he says

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Here we find increased proportion of pro-inflammatory and mesenchymal fibroblast subpopulations and senescent fibroblasts, and enhanced expression of senescence-associated secretory phenotype genes using single-cell RNA sequencing analysis, as well as elevated p16 protein and more -galactosidase-positive cells in keloids

Research in cell culture and rodent models consistently demonstrates that MOTS-c accelerates this translocation independently of insulin, offering a distinct and additive mechanism to insulin sensitizers like Metformin [1]