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Proinflammatory cytokines TNF- and IL1- activate the canonical NF-B pathway that induce the gene expression of cyclooxigenase-2, inducible nitric oxide synthase-3, inflammatory cytokines, and matrix metalloproteinases [75] These changes lead to the damage of TJs, decreased endothelial integrity and increased permeability at the BBB [73, 76], and to neuroinflammation and the development of chronic neurodegenerative diseases such as AD [10, 77]

Virus-induced interferon- causes insulin resistance in skeletal muscle and derails glycemic control in obesity

Due to their precise and targeted effects, certain peptides can be used therapeutically to aid in areas such as: Prescription peptides are medically regulated compounds that require oversight from a licensed healthcare provider

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