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The discrepancy between demonstrated subcutaneous efficacy (or lack thereof) and marketed oral supplements creates a fundamental problem: commercially available AOD-9604 supplements likely deliver negligible systemic peptide due to oral bioavailability limitations

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Conversely, given the particularity of our L-DOPA diet (an amino acid analog within a low sucrose concentration) and the complexity of the mosquito digestion system (sugar and protein meals have distinct compartmentalization) 71 , the enhanced resistance to parasite burden exhibited by L-DOPA-fed mosquitoes might reflect multifactorial mechanisms