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Lack of approval reflects insufficient human clinical trial data and incomplete evaluation of risks, dosing, and long-term effects

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At minimum, their antioxidant properties complement melatonins actions in neutralizing the oxidative stress that accumulates with age and circadian misalignment ( To illustrate some of these findings, Table 2 provides a few examples of nutritional interventions studied for their effects on melatonin levels, sleep quality, and circadian-related outcomes in middle-aged or elderly populations: TABLE 2 Selected nutritional interventions as chronobiotics in aging

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