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Because AOD9604 does not stimulate IGF-1 production and lacks strong GH receptor agonism, it may present a safer alternative for long-term OA treatment [1]
Providers should transition to emerging weight loss peptides when a patient experiences intractable side effects (like severe nausea or gastroparesis), when they hit a hard weight loss plateau despite dietary compliance, or when the primary clinical obstacle is documented cellular metabolic resistance rather than hyperphagia (overeating)
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