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In pathological hypertrophy conditions, miR-133 expression is drastically decreased, allowing activation of hypertrophic pathways such as the MEK-ERK1/2 Pathway (Li et al., 2018)
Ayton S, Lei P, Duce JA, Wong BXW, Sedjahtera A, Adlard PA et al
Astrocytes maintain their antioxidative functions through two primary mechanisms: the Nrf2keap1antioxidant response element (ARE) pathway and glutathione (GSH) synthesis
Antioxidant and Anti-Fibrotic Effects: GHK-Cu provides copper-dependent activation of superoxide dismutase (SOD) and other antioxidant enzymes that neutralize reactive oxygen species
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