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Alcohol metabolism can produce oxidative byproducts that can harm your liver and deplete your body's natural antioxidant stores
The proton-motive force created by the ETC is also used for many additional mitochondrial processes, especially those related with transport across the IMM (Kulawiak et al., 2013)
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Normally, almost all glutathione in the mitochondria is reduced glutathione, but in the presence of mitochondrial dysfunction, the proportion of oxidised glutathione increases due to the increased elimination of ROS
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