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The dual-mechanism approach may also offer specific advantages for particular patient subgroups, including those with type 2 diabetes and obesity where cardiometabolic improvements beyond weight loss are clinically important

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Role of ferroptosis in AD The regulation of ferroptosis can impact AD through multiple mechanisms, including the regulation of GSH levels, the Fenton reaction, amyloid- (A), lipid metabolism, iron metabolism and the NRF2 signaling pathway (Fig

First, as a branched chain fatty acid, VPA combines with carnitine to form valproylcarnitine, which is excreted in urine [42]