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The investigators used telomerase-negative human fetal fibroblast lines, treating with Epithalon at multiple concentrations and measuring telomerase activity by TRAP assay and telomere length by Southern blot
For patients requiring additional weight loss, titration to the higher maintenance dose (phentermine 15 mg/topiramate 92 mg) may occur, typically via an intermediate step (phentermine 11.25 mg/topiramate 69 mg for 14 days)
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