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Since Ca 2+ -dependent exocytosis of GLP-1 from L-cells is stimulated by ingested nutrients 17,18,19 , orally administered JWU-A021 might activate intestinal TRPA1 channels so that it replicates the GLP-1 secretagogue effect of such nutrients
PubMed: 26787572Clinical (RCT / meta-analysis) ref-9.Papi A, Di Stefano AF, Radicioni M Pharmacokinetics and Safety of Single and Multiple Doses of Oral N-Acetylcysteine in Healthy Chinese and Caucasian Volunteers: An Open-Label, Phase I Clinical Study
Thus, iron overload is inferred to cause bone damage by promoting osteoclast activity while simultaneously suppressing the formation of osteoblasts
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