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Biomarker Verification To verify target engagement in humans without direct hippocampal transcriptomics, peripheral proxy markers must be monitored: For Intranasal GHK-Cu (Metabolic Dampening): Monitor systemic proxies for mTOR suppression and mitochondrial load
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Consequently, the authors suggest that the peptide may engage a caspase-3/7-dependent route downstream of mitochondrial stress
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