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Traditional ways of increasing NO levels with nitroglycerin or other organic nitrates have limited clinical utility, mainly owing to unfavourable pharmacokinetics and the development of tolerance

However, the prolonged accumulation of senescent cells can paradoxically induce cancer development and various age-related diseases by inducing an inflammatory environment via the SASP 47-49

Lord C, Risi S, Lambrecht L, Cook EH, Leventhal BL, DiLavore PC, Pickles A, Rutter M: The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism

G., Lim, S