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Overall, the lack of a link between clinical measures of disease severity in NHPs and the experimental conditions associated with exacerbated lung pathology is a limitation to their utility in predicting the risks of ADE associated with passive-antibody or vaccine interventions in humans

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Research indicates the peptide crosses the blood-brain barrier, potentially offering neuroprotective benefits (Sikiric et al., Current Pharmaceutical Design, 2020)

J Clin Invest 2014;124:4473-88.ArticlePubMedPMC 58