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When adverse effects do occur following high-dose B12 administration, they are typically mild, transient, and often related to the route of administration rather than the vitamin itself
Luckily, we no longer have to rely on poorly absorbed oral supplements to meet our vitamin needs
In clinical deficiency states, usually as a result of insufficient absorption of vitamin B12, such as after extensive small bowel resection and small bowel irritation (dysbiosis of the bowel), the resorption area becomes smaller or blocked
A systematic review and meta-analysis used to inform international PCOS guidelines discusses potential benefits and limitations (Fitz et al., 2024) in PubMeds record for the review
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