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however, they decline during the second half of pregnancy.190 Nevertheless, even with this decline, concentrations of the CRH-binding protein exceed those of CRH by approximately 10-fold in the third trimester (2700 pmol/L vs 270 pmol/L, respectively).191, 192 Over the final 56 weeks of normal pregnancy, and before the onset of spontaneous preterm labor, the concentration of CRH-binding protein falls by approximately 50% before returning to normal levels by 5 days postpartum.177 Thus, plasma CRH concentration increases and CRH-binding protein decreases at a time when the structural and functional changes that are associated with parturition are occurring in gestational tissue.193 Expression of CRH Receptors in the Placenta CRH exerts its actions by binding to two different families of CRH receptors, termed CRH-R1 and CRH-R2.177 CRH-R1 and CRH-R2 are 415 and 411 amino acids in length, respectively, and each has several isoforms