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The confusion is understandable, because the word cycling gets used loosely to mean anything from two days off a week to two months off between courses
is that they have evolved as a result of a need for a higher regulatory input in Wnt signaling in the adult tissue stem cells frequently seen in long-lived vertebrates (Clevers et al., Lgr5 especially, has garnered much attention the last few years as a high fidelity marker of stem cells in several regenerating tissues (Schuijers and Clevers, 2012)
To prove that YBX1 functions by binding to mRNAs, we performed an RIP using the anti-YBX1 antibody and found that YBX1 can indeed bind to its own mRNA and also PRKAA1 /2 mRNAs in Huh7 and H1299 cells (Fig
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