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Notably, these substances exhibit two key characteristics: the "low-dose effect", where significant biological responses can occur at very low concentrations, and the "critical window of exposure effect", meaning that exposure during sensitive developmental stagessuch as the embryonic, infant, and pubertal periodsis more likely to cause persistent or even irreversible physiological damage [15]
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It has been found that MSC derived vesicles rescued the frequency of Tregs, and suppressed the expression of IL-4, GM-CSF, IFN-, IL-2, TNF-
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