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Studies in mice demonstrated that a short course of MOTS-c treatment completely reversed age-related insulin resistance in old muscles after one week of MOTS-c administration, older mices muscles responded to insulin as effectively as those of much younger mice

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For instance, female mice administered BSO exhibited much higher susceptibility to acetaminophen-induced hepatotoxicity than male mice [43], while male mice treated with BSO were much more susceptible to thiabendazole nephrotoxicity than females [44]