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Motif analysis of downregulated genes in both Ndufs2 and Bmal1 KO adipocytes revealed shared enrichment for C/EBP and SP family transcription factor motifs (Fig
Although the reasons for these differences are still being explored, they underline how personalised and regionally tailored support may improve outcomes
In addition, pharmacovigilance studies have reported signals of neuropsychiatric adverse events associated with GLP-1 receptor agonists, particularly in vulnerable populations such as individuals with prior psychiatric disorders or rapid weight loss [17, 53,54,55]
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